Cancer Gets Creamed

WHEN a disease runs skin deep, perhaps all that is needed is moisturizer supercharged with gene-regulation technology.

For skin conditions including melanoma, treatments that are applied directly to the skin are the ideal drug solution: they are easy to use and they affect only the area under which they are applied.

The problem is that our skin is such a successful barrier against toxins that finding substances that penetrate it is a huge challenge, says Amy Paller at Northwestern University’s Feinberg School of Medicine in Chicago. So until now, clinics have used lasers or ultrasound to help deliver drugs deep into the skin.

Paller and her colleague Chad Mirkin, also at Northwestern, have found a way through the skin barrier. They coated tiny gold spheres with small interfering RNA (siRNA) – tiny pieces of nucleic acid that appear to penetrate the barrier and enter skin cells through an as-yet unspecified pathway. The siRNA is selected to target one of the genes responsible for making cancer cells grow quickly, called epidermal growth factor receptor.

Paller and Mirkin mixed the drug with store-bought moisturizer and applied it to mouse skin. Not only did the nanoparticles penetrate the skin, but they also targeted the intended gene without causing toxicity or other side effects in the surrounding skin.

Attribution: New Scientist

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About thecommonconstitutionalist

Brent is not a scholar. He’s not an author or speaker (yet). He hasn’t published a book nor does he write articles for magazines (yet). He has no advanced literary degree or pedigree (never will). He is just an American who writes and shares what interests him. He cares about the salvation of this country and a return to its Constitutional roots. He believes in God, country and family.
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2 Responses to Cancer Gets Creamed

  1. Jarrett Cuoco says:

    Skin cancer is always preventable if you just use SPF sunblock creams when going out in the sun for a very long time. UV is the main cause of skin cancer and we should avoid it. “”:`.

    Thanks again
    http://www.healthmedicinelab.com“>

  2. Williemae Minardo says:

    Most of the time, skin cancer is caused by too much exposure to UV radiation and malnutrition. –

    Most interesting brief article on our own blog site
    http://www.foodsupplementdigest.com/liquid-melatonin-for-children/

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